Paul M. Leeson: шукати на сайті Z-Library

Fiona C. Ross, Nigel P. Botting, Paul D. Leeson

Рік:

1996

Мова:

english

Файл:

PDF, 177 KB

english, 1996

Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase

Журнал:

Fiona C Ross, Nigel P Botting, Paul D Leeson

Рік:

1996

Мова:

english

Файл:

PDF, 224 KB

english, 1996

Synthesis of 2S-[2-2H]-kynurenine and use in kinetic isotope effect studies with kynureninase

Журнал:

Tetrahedron

Рік:

1997

Мова:

english

Файл:

PDF, 573 KB

english, 1997

The influence of drug-like concepts on decision-making in medicinal chemistry

Leeson, Paul D., Springthorpe, Brian

Журнал:

Nature Reviews Drug Discovery

Рік:

2007

Мова:

english

Файл:

PDF, 541 KB

english, 2007

Time-Related Differences in the Physical Property Profiles of Oral Drugs

Leeson, Paul D., Davis, Andrew M.

Журнал:

Leeson, Paul D., Iversen, Leslie L.

Рік:

2004

Мова:

english

Файл:

PDF, 563 KB

english, 2004

The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Therapeutic Potential

Журнал:

Hickey, Deirdre M. B., Leeson, Paul D., Novelli, Riccardo, Shah, Virendra P., Burpitt, Brian E., Crawford, Lynne P., Davies, Bryan J., Mitchell, Michael B., Pancholi, Kirit D., Tuddenham, David, Lewis

Рік:

1994

Мова:

english

Файл:

PDF, 2.50 MB

english, 1994

Synthesis of thyroid hormone analogues. Part 3. Iodonium salt approaches to SK&F L-94901

Журнал:

Journal of the Chemical Society Perkin Transactions 1

Рік:

1988

Мова:

english

Файл:

PDF, 1.19 MB

english, 1988

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor

Leeson, Paul D., Baker, Raymond, Carling, Robert W., Curtis, Neil R., Moore, Kevin W., Williams, Brian J., Foster, Alan C., Donald, Angus E., Kemp, John A., Marshall, George R.

Журнал:

Leeson, Paul D., Emmett, John C., Shah, Virendra P., Showell, Graham A., Novelli, Ricardo, Prain, H. Douglas, Benson, Martin G., Ellis, David, Pearce, Nigel J., Underwood, Anthony H.

Рік:

1991

Мова:

english

Файл:

PDF, 1.82 MB

english, 1991

Selective thyromimetics. Cardiac-sparing thyroid hormone analogs containing 3'-arylmethyl substituents

Журнал:

Leeson, Paul D., Emmett, John C.

Рік:

1989

Мова:

english

Файл:

PDF, 1.88 MB

english, 1989

Synthesis of thyroid hormone analogues. Part 1. Preparation of 3?heteroarylmethyl-3,5-di-iodo-L-thyronines via phenol?dinitrophenol condensation and relationships between structure and selective thyromimetic activity

Журнал:

Journal of the Chemical Society Perkin Transactions 1

Рік:

1988

Мова:

english

Файл:

PDF, 1.44 MB

english, 1988

Chlorinated Ethene Source Remediation: Lessons Learned

Stroo, Hans F., Leeson, Andrea, Marqusee, Jeffrey A., Johnson, Paul C., Ward, C. Herb, Kavanaugh, Michael C., Sale, Tom C., Newell, Charles J., Pennell, Kurt D., Lebrón, Carmen A., Unger, Marvin

Журнал:

Environmental Science & Technology

Рік:

2012

Мова:

english

Файл:

PDF, 2.23 MB

english, 2012

Molecular Inflation, Attrition and the Rule of Five

Leeson, Paul D.

Журнал:

Advanced Drug Delivery Reviews

Рік:

2016

Мова:

english

Файл:

PDF, 1.10 MB

english, 2016

Plant pest and disease diagnosis using electronic nose and support vector machine approach

Ghaffari, Reza, Laothawornkitkul, Jullada, Iliescu, Daciana, Hines, Evor, Leeson, Mark, Napier, Richard, Moore, Jason P, Paul, Nigel D, Hewitt, C Nicholas, Taylor, Jane E

Журнал:

Journal of Plant Diseases and Protection

Рік:

2012

Мова:

english

Файл:

PDF, 430 KB

english, 2012

OP 32 Hypertension self-management postpartum – The SNAP-HT pilot study – Can women do it better?

Cairns, Alexandra, Tucker, Katherine, Leeson, Paul, Mackillop, Lucy, Crawford, Carole, Baker, Natasha, Tebbutt, Julie, McManus, Richard

Журнал:

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Рік:

2017

Мова:

english

Файл:

PDF, 731 KB

english, 2017

156 The Effectiveness of Physical Activity Interventions to Reduce Blood Pressure in Young Adults with Increased Cardiovascular Risk: A Systematic Review and Meta-Analysis

Williamson, Wilby, Reid, Hamish, Boardman, Henry, Lewandowski, Adam James, Kelly, Paul, Roberts, Nia, Foster, Charlie, Leeson, Paul

Журнал:

Heart

Рік:

2015

Мова:

english

Файл:

PDF, 80 KB

english, 2015

Do Young Women Need Treatment for Hypertension After Pregnancy Complications?

Aye, Christina Y. L., Elmahi, Einas, Boardman, Henry, Leeson, Paul

Журнал:

Journal of the American Heart Association

Рік:

2018

Мова:

english

Файл:

PDF, 666 KB

english, 2018

Artificial Intelligence in Cardiovascular Imaging

Dey, Damini, Slomka, Piotr J., Leeson, Paul, Comaniciu, Dorin, Shrestha, Sirish, Sengupta, Partho P., Marwick, Thomas H.

Журнал:

Journal of the American College of Cardiology

Рік:

2019

Файл:

PDF, 1.72 MB

2019

Data Science of the Natural Environment: A Research Roadmap

Blair, Gordon S., Henrys, Peter, Leeson, Amber, Watkins, John, Eastoe, Emma, Jarvis, Susan, Young, Paul J.

Журнал:

Frontiers in Environmental Science

Рік:

2019

Мова:

english

Файл:

PDF, 828 KB

english, 2019

Design kombinatorischer Leitstruktur-Bibliotheken

Simon J. Teague, Andrew M. Davis, Paul D. Leeson, Tudor Oprea

Журнал:

Angewandte Chemie

Рік:

1999

Мова:

german

Файл:

PDF, 157 KB

german, 1999

ChemInform Abstract: Is There a Difference Between Leads and Drugs? A Historical Perspective.

Tudor I. Oprea, Andrew M. Davis, Simon J. Teague, Paul D. Leeson

Журнал:

ChemInform

Рік:

2001

Файл:

PDF, 25 KB

2001

Precipitation and 13C-NMR relaxation enhancement measurements of the interactions of bile acids with synthetic cationic bile acid derivatives, and with spin labelled fatty acids

David G. Reid, Kaushika Gajjar, Simon P. Robinson, Deirdre M.B. Hickey, G.Martin Benson, Claire Haynes, Paul D. Leeson, Caroline M. Whittaker

Журнал:

Chemistry and Physics of Lipids

Рік:

1991

Мова:

english

Файл:

PDF, 554 KB

english, 1991

Tetramic acids as novel glycine site antagonists

Ian M. Mawer, Janusz J. Kulagowski, Paul D. Leeson, Sarah Grimwood, George R. Marshall

Журнал:

Рік:

1995

Мова:

english

Файл:

PDF, 212 KB

english, 1995

Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

Neil R. Curtis, Janusz J. Kulagowski, Paul D. Leeson, Ian M. Mawer, Mark P. Ridgill, Michael Rowley, Sarah Grimwood, George R. Marshall

Журнал:

Janis Gulens, Paul K Leeson, Luc Séguin

Рік:

1996

Мова:

english

Файл:

PDF, 261 KB

english, 1996

Kinetic influences on studies of copper(II) hydrolysis by copper ion-selective electrode

Журнал:

Analytica Chimica Acta

Рік:

1984

Мова:

english

Файл:

PDF, 902 KB

english, 1984

Synthesis of iminomethano-dibenzo[a,e]cyclooctenes by transannular formation and cleavage of isoxazolidines

Robert W Carling, Paul D Leeson

Журнал:

Tetrahedron Letters

Рік:

1988

Мова:

english

Файл:

PDF, 249 KB

english, 1988

Anticonvulsant activity of glycine-site NMDA antagonists. 1. 2-carboxyl prodrugs of 5,7-dichlorokynurenic acid

Kevin W. Moore, Paul D. Leeson, Robert W. Carling, Mark D. Ticklebank, Lakhbir Singh

Журнал:

Рік:

1993

Мова:

english

Файл:

PDF, 255 KB

english, 1993

Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.

Robert W. Carling, Paul D. Leeson, Angela M. Moseley, Julian D. Smith, Kay Saywell, Mark D. Tricklebank, John A. Kemp, George R. Marshall, Alan C. Foster, Sarah Grimwood

Журнал:

Рік:

1993

Мова:

english

Файл:

PDF, 448 KB

english, 1993

Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor

Paul D. Leeson, Brian J. Williams, Michael Rowley, Kevin W. Moore, Raymond Baker, John A. Kemp, Tony Priestley, Alan C. Foster, Angus E. Donald

Журнал:

Graeme I. Stevenson, Paul D. Leeson, Michael Rowley, Ian Sanderson, Ian Stansfield

Рік:

1993

Мова:

english

Файл:

PDF, 432 KB

english, 1993

Synthesis of cis and trans 4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor

Журнал:

Рік:

1992

Мова:

english

Файл:

PDF, 247 KB

english, 1992

2-carboxy indolines and indoles as potential glycine/NMDA antagonists: effect of five-membered ring conformation on affinity.

Michael Rowley, Paul D. Leeson, Sarah Grimwood, Alan Foster, Kay Saywell

Журнал:

Рік:

1992

Мова:

english

Файл:

PDF, 237 KB

english, 1992

Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists

Paul D. Leeson, Raymond Baker, Robert W. Carling, Janusz J. Kulagowski, Ian M. Mawer, Mark P. Ridgill, Michael Rowley, Julian D. Smith, Ian Stansfield, Graeme I. Stevenson, Alan C. Foster, John A. Kem

Журнал:

Рік:

1993

Мова:

english

Файл:

PDF, 390 KB

english, 1993

Adenosine-2′-monophosphate derivatives: Structural requirements as substrates for inositol monophosphatase

Paul D. Leeson, Kim James, Ian C. Lennon, Nigel J. Liverton, Sue Aspley, Rosamond G. Jackson

Журнал:

Adrian L. Smith, Christopher G. Thomson, Paul D. Leeson

Рік:

1993

Мова:

english

Файл:

PDF, 431 KB

english, 1993

An efficient solid phase synthetic route to 1,3-disubstituted 2,4(1H,3H)-Quinazolinediones suitable for combinatorial synthesis

Журнал:

Рік:

1996

Мова:

english

Файл:

PDF, 240 KB

english, 1996

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands

Neil R. Curtis, Janusz J. Kulagowski, Paul D. Leeson, Mark P. Ridgill, Frances Emms, Stephen B. Freedman, Shil Patel, Smita Patel

Журнал:

Рік:

1999

Мова:

english

Файл:

PDF, 195 KB

english, 1999

4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors

Kevin W. Moore, Katrine Bonner, Elizabeth A. Jones, Frances Emms, Paul D. Leeson, Rosemary Marwood, Shil Patel, Smita Patel, Michael Rowley, Steven Thomas, Robert W Carling

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

1999

Мова:

english

Файл:

PDF, 255 KB

english, 1999

Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors

Graham A. Showell, Frances Emms, Rosemarie Marwood, Desmond O'Connor, Smita Patel, Paul D. Leeson

Журнал:

Рік:

1998

Мова:

english

Файл:

PDF, 723 KB

english, 1998

3-(1-Piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels

Ian Collins, Michael Rowley, William B Davey, Frances Emms, Rosemarie Marwood, Shil Patel, Smita Patel, Alan Fletcher, Ian C Ragan, Paul D Leeson, Ann L Scott, Theodore Broten

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

1998

Мова:

english

Файл:

PDF, 238 KB

english, 1998

Next generation therapeutics: Editorial overview

Paul D Leeson, David C Rees

Журнал:

Current Opinion in Chemical Biology

Рік:

1999

Мова:

english

Файл:

PDF, 442 KB

english, 1999

Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance

Monique R Robinson, Michaela Scheuermann-Freestone, Paul Leeson, Keith M Channon, Kieran Clarke, Stefan Neubauer, Frank Wiesmann

Журнал:

Рік:

2008

Мова:

english

Файл:

PDF, 586 KB

english, 2008

Aortic distensibility decreases during exercise in normal volunteers

Alex Pitcher, Paul Leeson, Colin Forfar, Corinne Trevitt, Jane M Francis, Stefan Neubauer, Steffen E Petersen

Журнал:

Рік:

2010

Мова:

english

Файл:

PDF, 182 KB

english, 2010

Myocardial systolic strain assessed by cardiovascular magnetic resonance relates to subclinical atherosclerosis in healthy young adults

Adam J Lewandowski, Merzaka Lazdam, Jonathan Diesch, Jane M Francis, Daniel Augustine, Rajarshi Banerjee, Joseph J Suttie, Stefan Neubauer, Paul Leeson

Журнал:

Рік:

2011

Мова:

english

Файл:

PDF, 180 KB

english, 2011

Visualisation of aortic flow disturbance in Marfan syndrome by 4D phase-contrast CMR

Alex Pitcher, Tom E Cassar, Joseph Suttie, Jane M Francis, Paul Leeson, Edward Blair, B Paul Wordsworth, Colin J Forfar, Saul G Myerson, Michael Markl, Stefan Neubauer, Steffen E Petersen

Журнал:

Рік:

2011

Мова:

english

Файл:

PDF, 762 KB

english, 2011

Aortic dissection: visualisation of aortic blood flow and quantification of wall shear stress using time-resolved, 3D phase-contrast MRI

Alex Pitcher, Tom E Cassar, Paul Leeson, Jane M Francis, Edward Blair, Paul B Wordsworth, Colin J Forfar, Steffen E Petersen, Michael Markl, Stefan Neubauer

Журнал:

Рік:

2011

Мова:

english

Файл:

PDF, 338 KB

english, 2011

CMR right ventricular strain assessment using feature tracking cine images: agreement with echocardiography

Daniel Augustine, Joseph J Suttie, Peter Cox, Adam J Lewandowski, Cameron Holloway, Steffen E Petersen, Saul Myerson, Stefan Neubauer, Paul Leeson

Журнал:

Рік:

2012

Мова:

english

Файл:

PDF, 244 KB

english, 2012

Gender specific differences in left ventricular remodelling in obesity may explain differences in obesity related mortality

Oliver J Rider, Adam J Lewandowski, Richard Nethononda, Steffen E Petersen, Alex Pitcher, Cameron Holloway, Rajarshi Banerjee, James P Byrne, Paul Leeson, Stefan Neubauer

Журнал:

Рік:

2012

Мова:

english

Файл:

PDF, 199 KB

english, 2012

5,6,7,8-Tetrahydroquinolones as antagonists at the glycine site of the NMDA receptor

Michael Rowley, Paul Leeson, Sarah Grimwood, George Marshall, Kay Saywell

Журнал: